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NFL Week 6 Picks and Predictions Against the Spread: Steelers and Jets Shine in AFC Showdowns Against Raiders and Bills

Week 5 Recap: A Fruitful Week for Sporting News’ Picks

Week 5 proved to be a productive week for Sporting News’ picks and predictions against the spread. With a month of games and data on every team, analysts had a clearer picture of team strengths and weaknesses. However, the unpredictability of the NFL was on full display, as several games ended in dramatic, one-possession finishes. Notable nail-biters included the Jets vs. Vikings, 49ers vs. Cardinals, Bengals vs. Ravens, and Cowboys vs. Steelers, where outcomes didn’t align with our favored teams. Such anomalous results are part and parcel of the game, influenced by defensive takeaways and unexpected offensive or special teams blunders.

The Nature of Betting: Wins and Losses

In the world of sports betting, the mantra is simple: win more than you lose. Yet, this is often easier said than done. Each week presents a new slate of games filled with potential surprises. The unpredictability of the NFL means that while some bets may seem like sure things, unforeseen events can quickly turn the tide. As we dive into the Week 6 forecast, it’s essential to keep this in mind, as we offer fearless predictions for the upcoming matchups.

Betting Insights and Promotions

For those looking to get in on the action, there are some enticing betting promotions available. For instance, you can take advantage of the FanDuel promo, which offers a chance to bet $5 and get $200 guaranteed. Additionally, both DraftKings and FanDuel provide opportunities for prop bets, including anytime touchdown scorer options. For a comprehensive list of the best NFL betting sites, check out the latest odds from Caesars Sportsbook.

NFL Picks Against the Spread for Week 6

Game of Midweek: 49ers at Seahawks

Thursday 8:15 p.m. ET, Amazon Prime Video
The Seahawks began the season strong with a 3-0 record but have since cooled off to 3-2. Meanwhile, the 49ers are looking to bounce back from a disappointing 2-3 start. This matchup is crucial for both teams in the NFC West race, especially with the Rams and Cardinals struggling. The key for quarterbacks Geno Smith and Brock Purdy will be to avoid costly turnovers. Expect the 49ers to find success on the ground, with Jordan Mason supporting Purdy, ultimately leading to a narrow victory.
Pick: 49ers win 24-20 and cover the spread.

Game of the Week: Commanders at Ravens

Sunday 1 p.m. ET, CBS
This matchup features a thrilling duel between Heisman winners Jayden Daniels and Lamar Jackson. Both offenses have shown vulnerabilities, but Jackson’s experience and the addition of Derrick Henry give the Ravens a slight edge. Expect a high-scoring affair with plenty of explosive plays.
Pick: Ravens win 31-27 but fail to cover the spread.

Lock of the Week: Steelers over Raiders

Sunday 4:05 p.m. ET, CBS
The Steelers have faced tough opponents recently, but they will find a favorable matchup against the Raiders. With a run-heavy approach and T.J. Watt wreaking havoc on defense, Pittsburgh is poised for a dominant performance.
Pick: Steelers win 27-10 and cover the spread.

Upset of the Week: Buccaneers over Saints

Sunday 1 p.m. ET, Fox
The Buccaneers come into this game well-rested after a mini-bye, while the Saints are on a short week. Baker Mayfield is expected to shine in this divisional matchup, leading to a close victory for Tampa Bay.
Pick: Buccaneers win 27-24.

Jaguars at Bears

Sunday 9:30 p.m. ET, NFL Network (in London)
The Jaguars finally secured their first win of the season, but they face a tough challenge in London. The Bears, led by potential No. 1 overall pick Caleb Williams, are expected to capitalize on Jacksonville’s weaknesses.
Pick: Bears win 24-20 and cover the spread.

Cardinals at Packers

Sunday 1 p.m. ET, Fox
The Packers’ defense has been making strides under new coordinator Jeff Hafley. With Jordan Love expected to bounce back, Green Bay should secure a victory against the Cardinals.
Pick: Packers win 27-20 and cover the spread.

Texans at Patriots

Sunday 1 p.m. ET, CBS
The Texans are dealing with injuries but should rely on their running game and defense. The Patriots may find some spark with a potential QB change, but it won’t be enough to overcome Houston.
Pick: Texans win 23-20 but fail to cover the spread.

Browns at Eagles

Sunday 1 p.m. ET, Fox
The Eagles return from a bye with a healthier passing game. Expect Jalen Hurts to have a standout performance against a struggling Browns defense.
Pick: Eagles win 27-17 and cover the spread.

Colts at Titans

Sunday 1 p.m. ET, CBS
With key players potentially returning for the Colts, they should edge out the Titans in a close matchup.
Pick: Colts win 20-17 and cover the spread.

Chargers at Broncos

Sunday 4:05 p.m. ET, CBS
The Chargers are expected to exploit the Broncos’ weak run defense, leading to a comfortable victory.
Pick: Chargers win 23-10 and cover the spread.

Falcons at Panthers

Sunday 4:25 p.m. ET, Fox
The Falcons are primed to dominate this matchup, utilizing their strong passing game and running attack to secure a decisive win.
Pick: Falcons win 30-17 and cover the spread.

Lions at Cowboys

Sunday 4:25 p.m. ET, Fox
The Lions will rely on their running game, but turnovers could keep the Cowboys in the game. Expect a close finish.
Pick: Lions win 27-24 but fail to cover the spread.

Bengals at Giants

Sunday 8:20 p.m. ET, NBC
The Bengals need a strong performance from their offense to stay competitive. Look for Joe Burrow to lead a game-winning drive.
Pick: Bengals win 30-27 but fail to cover the spread.

Bills at Jets

Monday 8:15 p.m. ET, ESPN
The Jets are looking for a much-needed win against a struggling Bills defense. Expect a tight contest.
Pick: Jets win 23-20.

Stats of the Week

  • Week 5 Record Straight Up: 10-5
  • Week 5 Record Against the Spread: 10-5
  • Season-to-Date Straight Up: 49-30
  • Season-to-Date Against the Spread: 37-27

As we head into Week 6, the excitement of the NFL continues to build, with each game offering new opportunities for analysis, predictions, and, of course, betting.

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