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Week 6 College Football Picks and Predictions Against the Spread

College Football Week 6: A Friday Night Doubleheader and Rivalry Showdowns

As the leaves begin to change and the air turns crisp, college football fans are gearing up for an exciting Week 6. This week’s schedule is highlighted by a thrilling Friday night doubleheader and a mix of traditional and emerging conference rivalries. With several top-ranked teams in action, the stakes are high, and the excitement is palpable.

Friday Night Lights

The action kicks off on Friday night with two compelling matchups. At 9 p.m. ET, No. 25 UNLV will host Syracuse, aiming to keep their unbeaten streak alive under the guidance of head coach Barry Odom. The Rebels have been impressive this season, boasting a 4-0 record against the spread (ATS) and showcasing a potent offense led by dual-threat quarterback Hajj-Malik Williams. In their last outing, they dismantled Fresno State with a commanding 59-14 victory. However, Syracuse has struggled as a road underdog, going 1-6 ATS since 2022. While the Rebels are favored by 4.5 points, expect a closer game than the odds suggest.

Simultaneously, No. 6 Oregon will face Michigan State in a new-age Big Ten clash. The Ducks, under coach Dan Lanning, have been formidable at home, with a record of 14-1 straight up and 10-5 ATS as home favorites. Oregon’s quarterback Dillon Gabriel leads the nation with an impressive 81.5% completion rate, while Michigan State has struggled with turnovers, ranking last in the FBS. With the Ducks favored by 24 points, they are expected to cover the spread comfortably.

Saturday Showdowns

Saturday brings a full slate of games, including two top-10 teams facing off as underdogs. No. 9 Missouri will travel to No. 25 Texas A&M for a noon kickoff. Missouri, fresh off a bye week, boasts a balanced offense and a defense that limits opponents to a 50% completion rate. Despite being a road underdog, the Tigers are poised for an upset against the Aggies, who are tied with UNLV in the rankings.

At the same time, No. 10 Michigan will take on Washington in a highly anticipated rematch of last year’s College Football Playoff championship. The Wolverines are looking to prove themselves on the road, but they face a formidable opponent in the Huskies, who have been explosive on offense. Michigan’s defense will need to step up to secure a victory.

As the afternoon unfolds, No. 5 Georgia will clash with Auburn, and No. 3 Ohio State will host Iowa. Georgia is coming off a tough loss to Alabama and will look to bounce back against an Auburn team that has shown vulnerability. Meanwhile, Ohio State’s high-powered offense will test Iowa’s elite run defense, making for an intriguing matchup.

The late-night window features No. 8 Miami traveling to California, where they will face a Cal team that has shown resilience this season. With ESPN’s "College GameDay" making its first-ever appearance at Cal, the atmosphere is sure to be electric.

Key Matchups and Predictions

Among the notable matchups, the game between No. 12 Ole Miss and South Carolina stands out. The Rebels are looking to rebound after a surprising loss to Kentucky, while the Gamecocks, coming off a bye week, will be a tough challenge at home. Ole Miss’s dynamic offense, led by quarterback Jaxson Dart, will need to perform at its best to secure a win.

In another intriguing contest, No. 1 Alabama will face Vanderbilt. The Crimson Tide, currently atop the polls, have dominated their recent matchups against the Commodores. However, Alabama must avoid an emotional letdown after their big win against Georgia.

As the day progresses, No. 15 Clemson will visit Florida State, a game that was once anticipated to be a pivotal ACC showdown. The Seminoles have struggled offensively, making it difficult for them to compete against a resurgent Clemson team.

The Bigger Picture

While Week 6 may only feature one matchup between ranked teams, the excitement is building for the following week. October 12 promises to be a thrilling day in college football, with 17 games involving ranked FBS teams on the schedule. Fans and analysts alike are eager to see how the landscape of college football will shift as teams jockey for position in the playoff race.

With a track record of 70-16 straight up and 45-41 against the spread this season, predictions for Week 6 are sure to spark debate and discussion among fans. As the weekend approaches, the anticipation for these matchups continues to grow, setting the stage for an unforgettable week of college football.

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